Most anti-aging skincare focuses on wrinkles after they appear. Skin longevity starts much earlier, with the biology that determines how well skin repairs itself, maintains collagen, responds to hormones, and clears damaged or senescent cells.
I sat down with Dr. Saranya Wyles, MD, PhD, a Mayo Clinic dermatologist and regenerative medicine researcher, to separate useful science from a category full of hype. We cover sunscreen, visible light, facial estrogen, exercise, sauna, Botox, microcurrent, radiofrequency, retinol, exosomes, and the treatments that may support healthier skin over time.
We also explore why women's skin changes during menopause and across the menstrual cycle, how bone and facial fat influence visible aging, and why the right intervention depends on the decade, the tissue, and the problem you are actually trying to solve.
Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
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Brain Biohacking with Kayla Barnes — Dr. Saranya Wyles, MD, PhD: Skin Aging, Senescent Cells, Botox and Regenerative Dermatology
Most anti-aging skincare focuses on wrinkles after they appear. Skin longevity starts much earlier, with the biology that determines how well skin repairs itself, maintains collagen, responds to hormones, and clears damaged or senescent cells.
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I sat down with Dr. Saranya Wyles, MD, PhD, a Mayo Clinic dermatologist and regenerative medicine researcher, to separate useful science from a category full of hype. We cover sunscreen, visible light, facial estrogen, exercise, sauna, Botox, microcurrent, radiofrequency, retinol, exosomes, and the treatments that may support healthier skin over time.
We also explore why women's skin changes during menopause and across the menstrual cycle, how bone and facial fat influence visible aging, and why the right intervention depends on the decade, the tissue, and the problem you are actually trying to solve.
Track your sleep, recovery, strain, and HRV with WHOOP. Get one month free at https://join.whoop.com/kaylabarnes
Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.
https://kayla-barnes-lentz.circle.so/female-longevity-community
In This Conversation:
How senescent cells affect skin aging and repair
Why menopause accelerates collagen and skin changes
What sunscreen, antioxidants, and physical barriers actually do
Botox, facial exercises, microcurrent, and in-office devices
Retinol, exosomes, PRP, and regenerative skincare
How exercise, sleep, sauna, and the microbiome affect skin
Connect with Kayla:
Instagram: https://www.instagram.com/kaylabarnes/
TikTok: https://www.tiktok.com/@femalelongevity
Twitter:https://x.com/femalelongevity
Website:https://www.kaylabarnes.com/
Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054
Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227
Follow Her Female Protocol: https://www.protocol.kaylabarnes.com
Learn More About Dr. Saranya Wyles:
Mayo Clinic Profile: https://www.mayoclinic.org/biographies/wyles-saranya-p-m-d-ph-d/bio-20518649
Instagram: https://www.instagram.com/drwyles.derm/
LinkedIn: Saranya Wyles, M.D., Ph.D. | LinkedIn
X: https://x.com/drwyles_derm
#femalelongevity #skinlongevity #dermatology #senescentcells #skinaging #sunscreen #longevity #skincareroutine #hormonehealth #wellness
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